On a regular basis Consider patients, particularly when initiating and titrating dose and when given concomitantly with other drugs that depress respiration; alternatively, consider usage of non-opioid analgesics in these patients
Coadministration with CYP3A4 substrates, especially Those people with a narrow therapeutic index, can lead to reduced concentrations and loss of efficacy. If struggling to steer clear of coadministration, keep an eye on CYP3A4 substrate levels and alter dose as essential.
butorphanol decreases effects of fentanyl by pharmacodynamic antagonism. Prevent or Use Alternate Drug. Coadministration of mixed agonist/antagonist and partial agonist opioid analgesics may possibly lower fentanyl's analgesic effect and possibly precipitate withdrawal symptoms.
somatropin will minimize the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
eslicarbazepine acetate will lessen the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Carefully. Coadministration of fentanyl with CYP3A4 inducers could lead into a reduce in fentanyl plasma concentrations, not enough efficacy or, potentially, growth of a withdrawal syndrome in a individual who may have formulated Bodily dependence to fentanyl.
schisandra will increase the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
fentanyl will improve the level or effect of isavuconazonium sulfate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
benzhydrocodone/acetaminophen and fentanyl equally boost sedation. Avoid or Use Alternate Drug. Limit use to patients for whom different treatment options are insufficient
fentanyl intranasal and fentanyl both of those improve sedation. Stay clear of or Use Alternate Drug. Restrict use to patients for whom option treatment options are inadequate
isavuconazonium sulfate will improve the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 fentanyl tote usa metabolism. Use Caution/Monitor.
Life-threatening respiratory depression is a lot more likely to occur in elderly, cachectic, or debilitated patients because they may have altered pharmacokinetics or altered clearance in comparison with more youthful, healthier patients; check closely
buprenorphine transdermal and fentanyl the two maximize sedation. Stay clear of or Use Alternate Drug. Limit use to patients for whom option treatment options are inadequate
Narcotic agonist-analgesic of opiate receptors; inhibits ascending pain pathways, Hence altering response to pain; improves pain threshold; provides analgesia, respiratory depression, and sedation
B: Could possibly be acceptable. Possibly animal reports show no risk but human scientific tests not available or animal studies showed insignificant risks and human research accomplished and showed no risk.